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Check Closely (one)pentobarbital will decrease the level or impact of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to some lower in fentanyl plasma concentrations, deficiency of efficacy or, maybe, advancement of a withdra